High-Protein Pizza Breakfast Casserole

Featured in: Quick Lunches

This satisfying morning casserole combines the comfort of pizza flavors with a protein-packed start to your day. The Greek-yogurt dough creates a tender, golden base that's surprisingly simple to prepare. Layered with savory pizza sauce, whisked eggs, and topped with turkey pepperoni plus melted mozzarella and cheddar, this dish bakes up in just 25 minutes.

Perfect for meal prep or feeding a hungry crowd, each serving delivers 20 grams of protein while keeping calories at 270. Customize with bell peppers, red onions, or fresh herbs to suit your taste. The dough comes together with just self-rising flour and Greek yogurt—no yeast or rising time required.

Bake until the eggs are set and cheese bubbles golden brown. Let it rest briefly before slicing into squares that hold their shape beautifully for weekday breakfasts or weekend brunch gatherings.

Updated on Sun, 08 Feb 2026 21:51:26 GMT
Golden-brown High-Protein Pizza Breakfast Casserole slice served warm on a plate with a side of fresh fruit. Pin
Golden-brown High-Protein Pizza Breakfast Casserole slice served warm on a plate with a side of fresh fruit. | grillandbites.com

Kickstart your morning with a meal that brings the savory satisfaction of a pizzeria to your breakfast table. This High-Protein Pizza Breakfast Casserole uses a clever Greek-yogurt dough base topped with protein-rich eggs, flavorful turkey pepperoni, and a blend of melted cheeses, making it the perfect nutritious start to a productive day.

Golden-brown High-Protein Pizza Breakfast Casserole slice served warm on a plate with a side of fresh fruit. Pin
Golden-brown High-Protein Pizza Breakfast Casserole slice served warm on a plate with a side of fresh fruit. | grillandbites.com

This recipe is designed for those who want a hearty, filling breakfast without spending hours in the kitchen. By utilizing a simple two-ingredient-style dough, you create a sturdy and delicious crust that perfectly complements the fluffy egg topping.

Ingredients

  • Greek Yogurt Dough: 1 cup (245 g) plain Greek yogurt (2% or 0% fat), 1 cup (120 g) self-rising flour (plus extra for dusting), 1/2 tsp garlic powder, 1/2 tsp dried oregano, 1/4 tsp salt.
  • Toppings: 6 large eggs, 1/2 cup (120 ml) low-fat milk, 1 cup (110 g) shredded mozzarella cheese, 1/2 cup (50 g) shredded cheddar cheese, 1/2 cup (40 g) turkey pepperoni slices, 1/2 cup (125 ml) pizza sauce.
  • Optional Add-ins: 1/4 cup (25 g) diced bell pepper, 1/4 cup (25 g) diced red onion, 1 tbsp chopped fresh basil or parsley for garnish, salt and black pepper to taste.
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Instructions

1. Oven and Pan Prep
Preheat your oven to 400°F (200°C). Lightly grease a rimmed 9x13-inch sheet pan or line it with parchment paper.
2. Make the Dough
In a medium bowl, combine the Greek yogurt, self-rising flour, garlic powder, oregano, and salt. Mix until a shaggy dough forms, then knead on a floured surface for 2–3 minutes until smooth.
3. Shape the Base
Roll or press the dough into a rectangle and transfer it to the prepared pan, pressing it evenly to the edges.
4. Sauce Layer
Spread the pizza sauce evenly across the dough base.
5. Egg Mixture
In a large bowl, whisk together the eggs, milk, salt, and black pepper until well combined.
6. First Cheese Layer
Sprinkle half of the shredded mozzarella and cheddar cheese over the pizza sauce.
7. Combine
Pour the egg mixture evenly over the cheese layer.
8. Final Toppings
Top with the turkey pepperoni, the remaining cheese, and the optional bell peppers and red onions.
9. Bake
Bake for 22–25 minutes until the eggs are set and the cheese is golden and bubbly.
10. Rest and Garnish
Remove from the oven and let cool for 5 minutes. Garnish with fresh herbs, slice, and serve warm.

Zusatztipps für die Zubereitung

For the best dough consistency, ensure your Greek yogurt is not overly liquid; if it is, you may need to add a touch more flour during the kneading process. Pressing the dough firmly into the corners of the pan ensures a uniform thickness for even baking.

Varianten und Anpassungen

You can easily customize this casserole to suit your taste. For a spicier kick, add red pepper flakes to the egg mixture or swap the turkey pepperoni for spicy turkey sausage. You can also experiment with different vegetables like spinach or mushrooms to increase your daily fiber intake.

Serviervorschläge

This hearty casserole is a complete meal on its own, but it pairs beautifully with a fresh green salad or a side of seasonal fruit. For an extra pop of flavor, serve it with a side of extra pizza sauce for dipping or a drizzle of hot honey.

A whole pan of High-Protein Pizza Breakfast Casserole featuring bubbly cheese, turkey pepperoni, and diced bell peppers. Pin
A whole pan of High-Protein Pizza Breakfast Casserole featuring bubbly cheese, turkey pepperoni, and diced bell peppers. | grillandbites.com

Whether you are hosting a brunch or looking for a reliable way to meal prep your weekly breakfasts, this High-Protein Pizza Breakfast Casserole is a delicious and functional choice that the whole family will enjoy.

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Recipe FAQ

Can I make this ahead of time?

Yes, you can assemble the entire casserole the night before and refrigerate it. In the morning, let it sit at room temperature for 15 minutes while the oven preheats, then bake as directed.

What can I use instead of self-rising flour?

Substitute 1 cup all-purpose flour mixed with 1 ½ teaspoons baking powder and ¼ teaspoon salt. This combination creates the same rising effect as self-rising flour.

How should I store leftovers?

Store cooled portions in an airtight container in the refrigerator for up to 4 days. Reheat individual squares in the microwave for 1-2 minutes or in a 350°F oven until warmed through.

Can I freeze this casserole?

Yes, freeze baked and cooled squares in a single layer on a baking sheet, then transfer to a freezer bag for up to 3 months. Thaw overnight in the refrigerator before reheating.

How do I know when it's done baking?

The casserole is ready when the eggs are completely set—no jiggle in the center—and the cheese on top is melted and lightly golden. A knife inserted into the center should come out clean.

High-Protein Pizza Breakfast Casserole

Hearty morning casserole with Greek-yogurt crust, eggs, pepperoni and cheese.

Prep duration
20 min
Cook duration
25 min
Overall duration
45 min


Skill level Easy

Heritage American

Output 6 Portions

Dietary requirements None specified

Components

Greek Yogurt Dough

01 1 cup plain Greek yogurt, 2% or 0% fat
02 1 cup self-rising flour, plus extra for dusting
03 1/2 teaspoon garlic powder
04 1/2 teaspoon dried oregano
05 1/4 teaspoon salt

Toppings

01 6 large eggs
02 1/2 cup low-fat milk
03 1 cup shredded part-skim mozzarella cheese
04 1/2 cup shredded cheddar cheese
05 1/2 cup turkey pepperoni slices
06 1/2 cup low-sugar pizza sauce
07 1/4 cup diced bell pepper, optional
08 1/4 cup diced red onion, optional
09 1 tablespoon chopped fresh basil or parsley, optional for garnish
10 Salt and black pepper to taste

Directions

Phase 01

Prepare baking vessel: Preheat oven to 400°F. Lightly grease or line a 9x13-inch rimmed sheet pan with parchment paper.

Phase 02

Form dough base: In a medium bowl, combine Greek yogurt, self-rising flour, garlic powder, oregano, and salt. Mix until shaggy dough forms. Transfer to lightly floured surface and knead for 2-3 minutes until smooth.

Phase 03

Shape and pan dough: Roll or press dough into a rectangle to fit the prepared sheet pan. Transfer to pan and press evenly to all edges.

Phase 04

Layer pizza sauce: Spread pizza sauce evenly over the dough base in a thin, uniform layer.

Phase 05

Prepare egg mixture: In a large bowl, whisk together eggs, milk, a pinch of salt, and black pepper until well combined and uniform.

Phase 06

Add first cheese layer: Sprinkle half of the mozzarella and cheddar cheese over the pizza sauce.

Phase 07

Pour egg custard: Pour the egg mixture evenly over the cheese layer.

Phase 08

Assemble toppings: Top with turkey pepperoni, remaining cheese, bell pepper, and red onion if using.

Phase 09

Bake casserole: Bake for 22-25 minutes, or until eggs are set and cheese is golden and bubbly.

Phase 10

Rest and serve: Remove from oven and let cool for 5 minutes. Garnish with fresh basil or parsley if desired. Slice and serve warm.

Tools needed

  • Mixing bowls
  • Whisk
  • Rolling pin
  • 9x13-inch sheet pan
  • Parchment paper
  • Knife and cutting board

Allergy details

Review each ingredient for potential allergens and consult healthcare providers if you're uncertain about any components.
  • Contains wheat and gluten
  • Contains eggs
  • Contains milk and dairy products
  • Check pepperoni, cheese, and pizza sauce labels for additional allergens or processing additives.

Nutrition breakdown (per portion)

These values are estimates only and shouldn't replace professional medical guidance.
  • Energy: 270
  • Fat: 12 g
  • Carbohydrates: 20 g
  • Protein: 20 g